Full-length LGR5-positive cells have chemoresistant characteristics in colorectal cancer
نویسندگان
چکیده
منابع مشابه
Transcriptome profiling of LGR5 positive colorectal cancer cells
The concept of cancer stem cells (CSCs) claims that colorectal carcinomas (CRCs), like normal colorectal epithelium, are organized hierarchically and contain a subpopulation of qualitatively distinct cancer cells. The expression of distinctive surface markers or of certain enzymes is a prerequisite for the isolation and characterization of the CSC population. With respect to CRCs, putative CSCs...
متن کاملLGR5 positivity defines stem-like cells in colorectal cancer.
Like normal colorectal epithelium, colorectal carcinomas (CRCs) are organized hierarchically and include populations of cells with stem-like properties. Leucine-rich-repeat-containing G-protein-coupled receptor 5 (LGR5) is associated with these stem cells in normal colorectal epithelium; however, the precise function of LGR5 in CRC remains largely unknown. Here, we analyzed the functional and m...
متن کاملOverexpression of cancer stem cell marker Lgr5 in colorectal cancer patients and association with pathologic findings
Background: To determine the expression of cancer stem cell marker Leucine-rich repeat-containing G-protein coupled receptor 5 (Lgr5) in colorectal carcinoma samples compared to normal adjacent tissue and any possible association with clinicopathological findings. Methods: This study was performed on forty samples of cancerous colorectal tissues (case group) and their adjacent normal mucosa (c...
متن کاملRegulatory T Cells in Colorectal Cancer
One of the essential protection mechanisms of immune system is Treg cells which play an important role in maintenance ofimmune homeostasis. However, they may also inhibit immune functions against tumor cells. It has been reported that Treg cellsare increased in patients suffering from different types of cancer. Increased number of Treg cells has been shown in tumor lymphnodes, peripheral blood,...
متن کاملLgr5-Positive Cells are Cancer-Stem-Cell-Like Cells in Gastric Cancer.
BACKGROUND/AIMS Effective treatment of gastric cancer (GC) requires better understanding of the molecular regulation of its carcinogenesis. Identification of cancer stem cells (CSCs) in GC appears to be a critical question. METHODS We analyzed Lgr5 expression in GC specimen. We used an adeno-associated virus (AAV) that carries diphtheria toxin fragment A (DTA) under the control of Lgr5 promot...
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ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 2016
ISSN: 0007-0920,1532-1827
DOI: 10.1038/bjc.2016.112